[et_pb_section fb_built=”1″ _builder_version=”4.17.1″ _module_preset=”default” background_color=”#FFFFFF” custom_margin=”-52px||||false|false” global_colors_info=”{}”][et_pb_row _builder_version=”4.17.1″ _module_preset=”default” custom_margin=”-10px||-10px||false|false” custom_padding=”11px|||||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.17.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_text admin_label=”Text” _builder_version=”4.17.6″ _module_preset=”default” text_font=”Abel||||||||” text_text_color=”#404040″ text_font_size=”16px” link_font=”||||||||” link_text_color=”#404040″ link_font_size=”15px” background_color=”RGBA(255,255,255,0)” background_layout=”dark” min_height=”30px” custom_margin=”0px||0px|0px|false|false” custom_padding=”3px||0px|0px|false|false” global_colors_info=”{}”]<\/p>\n
Psychology > Faculty > Richard Bodnar > Opioid Receptor Subtypes<\/span><\/p>\n Shortly after the discovery of the opioid receptor in 1973, it became apparent that multiple opioid receptor subtypes (mu, delta, kappa and ORL-1) existed based on pharmacological, biochemical, anatomical and ultimately molecular evidence. Highly-specific and selective opioid receptor subtype agonists for the mu (e.g. DAMGO), delta-1 (e.g., DPDPE), delta-2 (e.g., deltorphin), kappa (e.g., U50488H) and ORL-1 (e.g., orphanin FQ-nociceptin) and antagonists for the mu (e.g., beta-funaltrexamine, CTOP), mu-1 (e.g., naloxonazine), delta (e.g., naltrindole) and kappa (e.g., nor-binaltorphamine) were developed and used by our laboratory and others to characterize which opioid receptor subtypes were involved in spontaneous intake and body weight gain in normal, developing, dietarily-obese and genetically-obese animals, in such regulatory challenges as food and water deprivation, glucoprivation and lipoprivation, in such stress-related issues as tail pinch feeding, and in such hedonic situations utilizing concentrations of sugars (e.g., sucrose), fats and starches (e.g., maltose dextrin). The orosensory characteristics of opioid function were studied using the sham-feeding paradigm minimizing post-ingestive factors.<\/p>\n Opioid Receptor Subtype and Feeding Publications of the Bodnar Laboratory:<\/strong><\/p>\n Bodnar, RJ.<\/strong>\u00a0Effects of opioid antagonists on feeding and appetite. In: Opioid Receptors and Antagonists: From Bench to Clinic, Contemporary Neuroscience Series, R Dean, E Bilsky and S Negus (Eds.) Humana Press: NJ, Chapter 20, pp. 379-398, 2008.<\/p>\n Bodnar, RJ.<\/strong>\u00a0and AS Levine. Role of opioid peptides in regulating energy balance. In: Neurobiology and Obesity, J Harvey and DJ Withers (Eds.) Cambridge University Press, U.K., Chapter 8, pp. 232-265, 2008. 180. Cole, JL, A Ross and RJ Bodnar. Dietary history affects the potency of chronic opioid receptor subtype antagonist effects upon body weight in rats. Nutritional Neuroscience 1: 405-418, 1999.<\/p>\n Bodnar, RJ.<\/strong>\u00a0Recent advances in the understanding of the effects of opioid agents on feeding and appetite. Exp. Opin. Invest. Drugs 7: 1-13, 1998. 168. Cole, JL, N Berman and RJ Bodnar. Differential sensitivity to body weight reductions following chronic central opioid receptor subtype antagonists in lean and obese Zucker rats. Peptides 18: 1201-1207, 1997.<\/p>\n Ruegg, H, W-Z Yu and\u00a0RJ Bodnar<\/strong>. Opioid receptor subtype agonist-induced enhancements of sucrose intake are dependent upon sucrose concentration. Physiol. Behav. 62: 121-128, 1997.<\/p>\n Yu, W-Z and\u00a0RJ Bodnar<\/strong>. Interactions between Angiotensin II and delta opioid receptor subtype agonists upon water intake in rats. Peptides 18: 241-245, 1997.<\/p>\n Yu, W-Z, H Ruegg and\u00a0RJ Bodnar<\/strong>. Delta and kappa opioid receptor subtypes and ingestion: Antagonist and glucoprivic effects. Pharmacol. Biochem. Behav. 56: 353-361, 1997.<\/p>\n Leventhal, L and\u00a0RJ Bodnar<\/strong>. Different central opioid receptor subtype antagonists modify maltose dextrin and deprivation-induced water intake in sham feeding and sham drinking rats. Brain Res. 741: 300-308, 1996.<\/p>\n Leventhal, L, JL Cole and\u00a0RJ Bodnar<\/strong>. Selective alterations in locomotor activity following central opioid receptor subtype antagonists in rats. Physiol. Behav. 60: 833-836, 1996.<\/p>\n Bodnar, RJ<\/strong>. Opioid receptor subtype antagonists and ingestion. In: Drug Receptor Subtypes and Ingestive Behavior, (Eds., SJ Cooper and PJ Clifton) Academic Press LTD: London, Chapter 6, 127-146, 1996.<\/p>\n Leventhal, L, TC Kirkham, JL Cole and\u00a0RJ Bodnar<\/strong>. Selective actions of central mu and kappa opioid antagonists upon sucrose intake in sham-feeding rats. Brain Res. 685: 205-210, 1995.<\/p>\n Cole, JL, L Leventhal, GW Pasternak, WD Bowen and\u00a0RJ Bodnar<\/strong>. Reductions in body weight following chronic central opioid receptor subtype antagonists during development of dietary obesity in rats. Brain Res. 678: 168-176, 1995.<\/p>\n Bodnar, RJ<\/strong>, MJ Glass and JE Koch. Analysis of central opioid receptor subtype antagonism of hypotonic and hypertonic saline intake in water-deprived rats. Brain Res. Bull. 36: 293-300, 1995.<\/p>\n Glass, MJ, B Hahn, A Joseph and\u00a0RJ Bodnar<\/strong>. Central opioid receptor subtype mediation of isoproterenol-induced drinking in rats. Brain Res. 657: 310-314, 1994.<\/p>\n Koch, JE and\u00a0RJ Bodnar<\/strong>. Selective alterations in macronutrient intake of food-deprived or gluco-privic rats by centrally-administered opioid receptor subtype antagonists. Brain Res. 657: 191-201, 1994.<\/p>\n Schaefer, LA, JE Koch and\u00a0RJ Bodnar<\/strong>. Naltrexone, dopamine receptor agonists and antagonists and food intake in rats: 2. 2-deoxy-D-glucose. Pharmacol. Biochem. Behav. 49: 205-211, 1994.<\/p>\n Hobbs, DJ, JE Koch and\u00a0RJ Bodnar<\/strong>. Naltrexone, dopamine receptor agonists and antagonists and food intake in rats: 1. Food deprivation. Pharmacol. Biochem. Behav. 49: 197-204, 1994.<\/p>\n Islam, AK, T Dougherty, JE Koch and\u00a0RJ Bodnar<\/strong>. Naltrexone, serotonin receptor subtype antagonists and carbohydrate intake in rats. Pharmacol. Biochem. Behav. 48: 193-201, 1994.<\/p>\n Ruegg, H, B Hahn, JE Koch and\u00a0RJ Bodnar<\/strong>. Differential modulation of angiotensin II and hypertonic saline-induced drinking by opioid receptor subtype antagonists in rats. Brain Res. 635: 203-210, 1994.<\/p>\n Islam, AK, IW Beczkowska and\u00a0RJ Bodnar<\/strong>. Interactions among aging, gender and gonadectomy effects upon naloxone hypophagia in rats. Physiol. Behav. 54: 981-992, 1993.<\/p>\n Beczkowska, IW, JE Koch, ME Bostock, SF Leibowitz and\u00a0RJ Bodnar<\/strong>. Central opioid receptor subtype antagonists differentially reduce intake of saccharin and maltose dextrin solutions in rats. Brain Res. 618: 261-270, 1993.<\/p>\n Koch, JE and\u00a0RJ Bodnar<\/strong>. Involvement of central mu1 and mu2 opioid receptor subtypes in tail-pinch feeding in rats. Physiol. Behav. 53: 603-605, 1993.<\/p>\n Beczkowska, IW, WD Bowen and\u00a0RJ Bodnar<\/strong>. Central opioid receptor subtype antagonists differentially alter sucrose and deprivation-induced water intake in rats. Brain Res. 589: 291-301, 1992.<\/p>\n Koch, JE, GW Pasternak, D Arjune and\u00a0RJ Bodnar<\/strong>. Naloxone benzoylhydrazone, a kappa3 opioid agonist, stimulates food intake in rats. Brain Res. 581: 311-314, 1992.<\/p>\n Koch, JE, IW Beczkowska and\u00a0RJ Bodnar<\/strong>. Naltrexone, serotonin receptor subtype antagonists and glucoprivic intake: II. insulin. Pharmacol. Biochem. Behav. 42: 671-680, 1992.<\/p>\n Beczkowska, IW, JE Koch and\u00a0RJ Bodnar<\/strong>. Naltrexone, serotonin receptor subtype antagonists and glucoprivic intake: I. 2-deoxy-D-glucose. Pharmacol. Biochem. Behav. 42: 661-669, 1992.<\/p>\n Arjune, D, WD Bowen and\u00a0RJ Bodnar<\/strong>. Ingestive behavior following central [D-Ala2,Leu5,Cys6]-enkephalin (DALCE), a short-acting agonist and long-acting antagonist at the delta opioid receptor. Pharmacol. Biochem. Behav. 39: 429-436, 1991.<\/p>\n Beczkowska, IW and\u00a0RJ Bodnar<\/strong>. Mediation of insulin hyperphagia by specific central opiate receptor antagonists. Brain Res. 547: 315-318, 1991.<\/p>\n Beczkowska, IW and\u00a0RJ Bodnar<\/strong>. Naloxone and serotonin receptor subtype antagonists: interactive effects upon deprivation-induced intake. Pharmacol. Biochem. Behav. 38: 605-610, 1991. Arjune, D and\u00a0RJ Bodnar<\/strong>. Suppression of nocturnal, palatable and glucoprivic intake in rats by the kappa opioid antagonist, nor-binaltorphamine. Brain Res. 534: 313-316, 1990.<\/p>\n Arjune, D, KM Standifer, GW Pasternak and\u00a0RJ Bodnar<\/strong>. Reduction by central beta-funaltrexamine of food intake in rats under freely-feeding, deprivation and glucoprivic conditions. Brain Res. 535: 101-109, 1990.<\/p>\n Arjune, D and\u00a0RJ Bodnar<\/strong>. Inhibition of deprivation-induced feeding by naloxone and cholecystokinin in rats: effects of central alloxan. Brain Res. Bull. 24: 375-379, 1990.<\/p>\n Islam, AK and\u00a0RJ Bodnar<\/strong>. Selective opioid receptor antagonist effects upon intake of a high-fat diet in rats. Brain Res. 508: 293-296, 1990.<\/p>\n Bodnar, RJ<\/strong>, GW Pasternak, PE Mann, D Paul, R Warren and DB Donner. Tumor necrosis factor (TNF) induces anorexia in the rat: evidence for a peripherally-mediated action. Cancer Res. 49: 6280-6284, 1989.<\/p>\n Mann, PE, GW Pasternak, EF Hahn, G Curreri, E Lubin and\u00a0RJ Bodnar<\/strong>. Comparison of chronic naloxone and naloxonazine effects upon food intake and body weight maintainance in rats. Neuropharmacol. 27: 349-355, 1988.<\/p>\n Mann, PE, D Arjune, M-T Romero, GW Pasternak, EF Hahn and\u00a0RJ Bodnar<\/strong>. Differential sensitivity of opioid-induced feeding to naloxone and naloxonazine. Psychopharmacol. 94: 330-341, 1988.<\/p>\n Bodnar, RJ<\/strong>, PE Mann, M-T Romero and LS Truesdell. Loss of morphine hyperphagia following neonatal monosodium glutamate treatment in rats. Life Sci. 38: 947-950, 1986.<\/p>\n Simone, DA,\u00a0RJ Bodnar<\/strong>, EJ Goldman and GW Pasternak. Involvement of opioid receptor subtypes in rat feeding behavior. Life Sci. 36: 829-833, 1985.<\/p>\n Bodnar, RJ<\/strong>\u00a0and PD Butler. Modulation of deprivation-induced food intake by D-phenylalanine. Int. J. Neurosci. 20: 295-301, 1983.<\/p>\n [\/et_pb_text][\/et_pb_column][et_pb_column type=”1_5″ _builder_version=”4.17.1″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" Psychology > Faculty > Richard Bodnar > Opioid Receptor Subtypes Opioid Receptor Subtypes and Ingestive Behavior Shortly after the discovery of the opioid receptor in 1973, it became apparent that multiple opioid receptor subtypes (mu, delta, kappa and ORL-1) existed based on pharmacological, biochemical, anatomical and ultimately molecular evidence. 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[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_5,3_5,1_5″ _builder_version=”4.17.4″ _module_preset=”default” custom_margin=”-25px||0px||false|false” custom_padding=”0px||||false|false” global_colors_info=”{}”][et_pb_column type=”1_5″ _builder_version=”4.17.1″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_column][et_pb_column type=”3_5″ _builder_version=”4.17.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_text admin_label=”Text” _builder_version=”4.17.6″ _module_preset=”default” text_font=”Roboto|300|||||||” text_text_color=”#333333″ text_font_size=”15px” link_text_color=”#0055aa” header_font_size=”24px” header_3_font=”Roboto||||||||” header_3_text_color=”#404040″ header_3_font_size=”24px” header_4_font=”Roboto||||||||” header_4_text_color=”#333333″ header_4_font_size=”19pt” header_5_text_color=”#333333″ custom_margin=”|-20px||-20px|false|false” global_colors_info=”{}”]<\/p>\nOpioid Receptor Subtypes and Ingestive Behavior<\/h4>\n