{"id":10621,"date":"2022-03-22T12:08:37","date_gmt":"2022-03-22T16:08:37","guid":{"rendered":"http:\/\/149.4.100.129\/academics\/bio\/?page_id=10621"},"modified":"2022-03-25T15:05:25","modified_gmt":"2022-03-25T19:05:25","slug":"karl-fath","status":"publish","type":"page","link":"https:\/\/www.qc.cuny.edu\/academics\/bio\/karl-fath\/","title":{"rendered":"Dr. Karl Fath"},"content":{"rendered":"

[et_pb_section fb_built=”1″ _builder_version=”4.15″ background_color=”rgba(0,0,0,0)” custom_padding=”16px|||||” global_colors_info=”{}”][et_pb_row column_structure=”1_4,3_4″ _builder_version=”4.15.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”1_4″ _builder_version=”4.15.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/www.qc.cuny.edu\/academics\/bio\/wp-content\/uploads\/sites\/117\/2022\/03\/Fath2005-e1396416697602.jpg” alt=”Karl Fath” title_text=”Karl Fath” align=”center” _builder_version=”4.15.1″ _module_preset=”default” border_width_all=”1px” border_color_all=”#000000″ global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”3_4″ _builder_version=”4.15.1″ _module_preset=”default” global_colors_info=”{}”][dsm_text_divider header=”Dr. Karl Fath” text_alignment=”left” color=”#E71939″ divider_position=”flex-end” divider_weight=”5px” _builder_version=”4.15.1″ _module_preset=”default” header_font=”Open Sans|600|||||||” header_text_color=”#000000″ header_font_size=”30px” global_colors_info=”{}”][\/dsm_text_divider][et_pb_text _builder_version=”4.15.1″ text_font=”Open Sans||||||||” text_font_size=”16px” header_4_font=”Open Sans|600|||on||||” text_orientation_tablet=”center” text_orientation_phone=”” text_orientation_last_edited=”on|desktop” global_colors_info=”{}”]Assistant Professor
\n(Ph.D.Case Western Reserve University)
\nCell polarity, Golgi membrane trafficking, cytoskeletal motors
\nOffice: NSB E -122 Tel: (718) 997- 3424
\nLaboratory: NSB E-133 Tel. (718) 997-3157
\nE-mail: karl.fath@qc.cuny.edu<\/em>
\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”3_5,2_5″ _builder_version=”4.15.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”3_5″ _builder_version=”4.15.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.15.1″ text_font=”Open Sans||||||||” text_font_size=”16px” header_4_font=”Open Sans|600|||on||||” text_orientation_tablet=”left” text_orientation_phone=”” text_orientation_last_edited=”on|desktop” global_colors_info=”{}”]My research is directed toward elucidation of the roles of the cytoskeleton in the formation and maintenance of cell polarity. Not only is the cytoskeleton a scaffold crucial to cell shape, it also serves as the tracks or highways upon which cell components are delivered to their correct cellular destinations. The constituents of the apical cytoskeleton and plasma membrane are important in the physiology of polarized intestinal epithelial cells. I have found that myosin-I, a nonmuscle actin-based motor, and dynein, a microtubule-based motor, are bound to Golgi-derived vesicles and may be important in the targeting and delivery to the apical plasma membrane domain. The mistargeting of plasma membrane proteins can cause illnesses such as microvillus inclusion disease and polycystic kidney disease, therefore, an understanding of delivery mechanisms may provide therapeutic tools.
\n[\/et_pb_text][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”4.15.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/www.qc.cuny.edu\/academics\/bio\/wp-content\/uploads\/sites\/117\/2022\/03\/BCOPActin-e1396539818242.jpg” alt=”A-549 (human epithelial-like cell line) cells double-labeled for polymerized actin (red) and the coatomer protein beta-COP (green), which is involved in membrane movement along the biosynthetic pathway.” title_text=”A-549 (human epithelial-like cell line) cells” align=”center” _builder_version=”4.15.1″ _module_preset=”default” border_width_all=”1px” border_color_all=”#000000″ global_colors_info=”{}”][\/et_pb_image][et_pb_text _builder_version=”4.15.1″ text_font=”Open Sans||||||||” text_font_size=”15px” header_4_font=”Open Sans|600|||on||||” text_orientation_tablet=”center” text_orientation_phone=”” text_orientation_last_edited=”on|desktop” global_colors_info=”{}”]<\/p>\n

A-549 (human epithelial-like cell line) cells double-labeled for polymerized actin (red) and the coatomer protein beta-COP (green), which is involved in membrane movement along the biosynthetic pathway.<\/p>\n

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Selected Publications:<\/strong><\/span><\/p>\n

Fath, K.R.<\/b> and D.R. Burgess. 1993. Golgi\u2013derived vesicles from developing epithelial cells bind actin filaments and possess myosin\u2013I as a cytoplasmically oriented peripheral membrane protein. J. Cell Biol.<\/i>, 120<\/b>:117\u2013127. \u00a0http:\/\/www.jcb.org\/cgi\/content\/abstract\/120\/1\/117<\/p>\n

Fath, K.R., <\/b>G.M. Trimbur <\/b>and D.R. Burgess. 1994. Molecular motors are differentially distributed on Golgi membranes from polarized epithelial cells. J. Cell Biol.<\/i>, 126<\/b>:661\u2013675. \u00a0http:\/\/www.jcb.org\/cgi\/content\/abstract\/126\/3\/661<\/p>\n

Ikonen, E., J.B. de Almeida, K.R. Fath<\/b>, D.R. Burgess, K. Ashman, K. Simons and J.L. Stow. 1997. Myosin II is associated with Golgi membranes: identification of p200 as nonmuscle myosin II on Golgi\u2013derived vesicles. J. Cell Sci.<\/i>, 110<\/b>:2155\u20132164. \u00a0http:\/\/jcs.biologists.org\/cgi\/reprint\/110\/18\/2155<\/p>\n

Fath<\/b>, K.R., <\/b>G.M. Trimbur and D.R. Burgess. 1997. Molecular motors and a spectrin matrix associate with Golgi membranes in vitro<\/i>. J. Cell Biol<\/i>., 139<\/b>:1169\u20131181. \u00a0http:\/\/www.jcb.org\/cgi\/content\/full\/139\/5\/1169<\/p>\n

Bo\u00ebda, B., A. El-Amraoui, A. Bahloul, R. Goodyear, L. Daviet, S. Blanchard, I. Perfettini, K. R. Fath<\/b>, S. Shorte, J. Reiners, A. Houdusse, P. Legrain, U. Wolfrum, G. Richardson, and C. Petit. <\/b>2002. <\/b>Myosin VIIa, harmonin, and cadherin\u00a023, three Usher I gene products that cooperate to shape the sensory hair cell bundle. EMBO J.,<\/i> 21<\/b>:6689-6699. \u00a0http:\/\/embojournal.npgjournals.com\/cgi\/content\/abstract\/21\/24\/6689<\/p>\n

Fath. K.R. <\/b>2005. <\/b>Characterization of myosin\u2013II binding to Golgi stacks in vitro.<\/i> Cell Motil. Cytoskeleton<\/i>, 60<\/b>:222-235. \u00a0<\/i>http:\/\/www3.interscience.wiley.com\/cgi-bin\/abstract\/110426105<\/p>\n

Spear, R.L., R. Tamayev, K.R. Fath<\/b> and I.A. Banerjee. 2007. Templated growth of calcium phosphate on tyrosine derived microtubules and their biocompatibility. Colloids Surf. B: Biointerfaces<\/i>. 60<\/b>:158-166.<\/p>\n

Henricus, M.M., K.R. Fath<\/b>, M.Z. Menzenski and I.A. Banerjee. 2009. Morphology controlled growth of chitosan-bound microtubes and a study of their biocompatibility and antibacterial activity. Macromolecular Bioscience<\/i>. 9<\/b>:317-325. doi:10.1002\/mabi.200800220<\/p>\n

Johnson, K.T., K.R. Fath<\/b>, M M. Henricus and I.A. Banerjee. 2009. Self-assembly and growth of smart cell-adhesive mucin-bound microtubes. Soft Materials<\/i>. 7<\/b>(1):21-36.<\/p>\n

Avanzato, C.P., J.M. Follieri, I.A. Banerjee <\/b>and K.R. Fath<\/b>. 2009. Growth of amino acid catalyzed magnesium oxide- germanium oxide nanocomposites and their antibacterial applications. Journal of Composite Materials<\/i>.<\/i> 43<\/b>:897-910. doi:10.1177\/0021998309103158.<\/p>\n

Barnaby, S.N., S.M. Yu, K.R. Fath<\/b>, A. Tsiola, O. Khalpari, I.A. Banerjee. 2011. Ellagic acid promoted biomimetic synthesis of shape-controlled silver nanochains. Nanotechnology.<\/i> 22<\/b>(22): 225605\u2013225614. doi:10.1088\/0957-4484\/22\/22\/225605.<\/p>\n

Barnaby, S.N., S.H. Frayne, K.R. Fath<\/b>, I.A. Banerjee. 2011. Growth of Se nanoparticles on kinetin assemblies and their biocompatibility studies. Soft Materials<\/i>. 9<\/b>(4):313-334.<\/i> doi:10.1080\/1539445X.2010.516302.<\/p>\n

Barnaby, S.N., S.M. Yu, A. Tsiola, K.R. Fath<\/b>, I.A. Banerjee. 2011. pH dependent spontaneous growth of ellagic acid assemblies for targeting HeLa cells. \u00a0J. Nanosci. Nanotech<\/i>. 11<\/b>(9):7579-7586. doi:10.1166\/jnn.2011.4709<\/p>\n

Smoak, E.M., K.R. Fath<\/b>, S.N. Barnaby, V.C. Grant, I.A. Banerjee. 2011. pH tunable self-assembly of chicoric acid and their biocompatibility studies. Supramolecular Chem<\/i>. 23<\/b>(10):678-688. doi:10.1080\/10610278.2011.601309.<\/p>\n

Nakatsuka, N., S.N. Barnaby, K.R. Fath<\/b>, I.A. Banerjee. 2012. Fabrication of collagen-elastin\u2013bound peptide nanotubes for mammalian cell attachment. J. Biomater. Sci. Polym.<\/i> Ed.<\/i> 22<\/b>(18): 1843-1862. doi: 10.1163\/156856211X598229; PMID: 21967742<\/b><\/p>\n

Barnaby, S.N., K.R. Fath<\/b>, A. Tsiola, I.A. Banerjee. 2012. Fabrication of ellagic acid incorporated self-assembled peptide microtubes and their applications. Colloids and Surfaces B: Biointerfaces<\/i>, 95<\/b>:154-161.<\/p>\n

Sarker, N.H., S.N. Barnaby, K.R.<\/b> Fath<\/b>, S.H. Frayne, N. Nakatsuka, I.A. Banerjee. 2012. Biomimetic growth of gallic acid\u2013ZnO hybrid assemblies and their applications. Journal of Nanoparticle Research<\/i>, 14<\/b>:1-12. doi: 10.4028\/www.scientific.net\/JBBTE.13.1.<\/p>\n

Barnaby, S.N., K.R. Fath<\/b>, N. Nakatsuka, N.H. Sarker, I.A. Banerjee. 2012. Formation of calcium phosphate-ellagic acid composites by layer by layer assembly for cellular attachment to osteoblasts. Journal of Biomimetics, Biomaterials & Tissue Engineering<\/i>, 13<\/b>:1-17.<\/p>\n

Barnaby, S.N., N. Nakatsuka, S.H. Frayne, K.R. Fath<\/b>, and I.A. Banerjee. 2013. Formation of hyaluronic acid\u2013ellagic acid microfiber hybrid hydrogels and their applications. Colloid and Polymer Science<\/i>, 291<\/b>:515-525. Online First. doi: 10.1007\/s00396-012-2739-2.<\/p>\n

Nakatsuka, N., S.N Barnaby, A. Tsiola, K.R. Fath<\/b>, B.A. Williams, and I.A. Banerjee. 2013. Self-assembling peptide assemblies bound to ZnS nanoparticles and their interactions with mammalian cells. Colloids and Surfaces B: Biointerfaces, <\/i>103:405-415. doi:10.1016\/j.colsurfb.2012.10.009. Epub 2012.<\/p>\n

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Dr. Karl Fath<\/span><\/h3>\n\t\t\t\t
<\/div>\n\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>Assistant Professor (Ph.D.Case Western Reserve University) Cell polarity, Golgi membrane trafficking, cytoskeletal motors Office: NSB E -122 Tel: (718) 997- 3424 Laboratory: NSB E-133 Tel. (718) 997-3157 E-mail: karl.fath@qc.cuny.edu My research is directed toward elucidation of the roles of the cytoskeleton […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","inline_featured_image":false,"footnotes":""},"page_category":[],"wf_page_folders":[134],"class_list":["post-10621","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.qc.cuny.edu\/academics\/bio\/wp-json\/wp\/v2\/pages\/10621","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.qc.cuny.edu\/academics\/bio\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.qc.cuny.edu\/academics\/bio\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.qc.cuny.edu\/academics\/bio\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.qc.cuny.edu\/academics\/bio\/wp-json\/wp\/v2\/comments?post=10621"}],"version-history":[{"count":0,"href":"https:\/\/www.qc.cuny.edu\/academics\/bio\/wp-json\/wp\/v2\/pages\/10621\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.qc.cuny.edu\/academics\/bio\/wp-json\/wp\/v2\/media?parent=10621"}],"wp:term":[{"taxonomy":"page_category","embeddable":true,"href":"https:\/\/www.qc.cuny.edu\/academics\/bio\/wp-json\/wp\/v2\/page_category?post=10621"},{"taxonomy":"wf_page_folders","embeddable":true,"href":"https:\/\/www.qc.cuny.edu\/academics\/bio\/wp-json\/wp\/v2\/wf_page_folders?post=10621"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}